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An intact late 19th century Ships Medicine chest has been analysed for the identification and quality of the historical herbal medicines contained in some of the 50 glass stoppered bottles. This is likely one of the best preserved items of its kind in Australia. The medicine chest was originally used on the SS St George, a steamship from England brought here by William Yaeger, which ran on the NSW north coast route from 1898 to 1915. This presentation discusses some of the history of the medicine chest, the uses of some of the herbal medicines within the chest and the constituents and quality of these medicines which are over a century old.